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19087 Responses

  1. Researchers from the College of Bonn handled mice with Viagra and
    made a tremendous discovery: The drug converts undesirable white fats
    cells and will thus probably melt the unwelcome “spare tire”
    across the midriff. As well as, the substance additionally decreases the danger of different complications attributable to
    obesity. The outcomes are actually revealed within the Journal of the
    Federation of American Societies for Experimental Biology (FASEB).

    Sildenafil – higher often called Viagra – is
    used to deal with erectile dysfunction. This substance prevents degradation of
    cyclic guanosine mono-phosphate (cGMP), which then ensures
    blood provide for an erection. Nevertheless, one other
    impact of Viagra has been observed fairly a while in the past – mice given sildenafil over longer intervals of
    time had been resistant to obesity when fed with excessive-fats weight-reduction plan. Nonetheless, the
    trigger for this lowered weight acquire had been unclear.

    Researchers from the College of Bonn have been in a position to shed some mild on this sildenafil
    impact. “We’ve got been researching the impact of cGMP on fats cells for fairly a while now,” studies Prof.
    Dr. Alexander Pfeifer, Director of the Institute for Pharmacology and Toxicology on the College of Bonn.
    “That is why sildenafil was a probably fascinating candidate for us.”

    Viagra converts undesirable white fats cells into
    beige ones

    Together with the PharmaCenter of the College of Bonn, the German Federal Institute
    for Medication and Medical Units (BfArM), and the Max Planck Institute for Coronary heart and
    Lung Analysis, the group round Prof. Pfeifer studied the impact of sildenafil on fats
    cells in mice. The researchers administered the potency drug
    to the rodents for seven days. “The consequences had been fairly wonderful,” says Dr.
    Ana Kilic, certainly one of Prof. Pfeifer’s colleagues. Sildenafil elevated the conversion of white
    fats cells, that are present in human ‘drawback areas’, into beige ones within the animals.
    “Beige fats cells burn the vitality from ingested meals and convert it to heat, says Prof. Pfeifer. As a result of the beige fats cells can “melt
    the fats” and thus struggle obesity, researchers are very hopeful for his or her potential.

    Positive impact on inflammation responses

    In addition, the researchers noticed one thing else of curiosity. If white fats cells are additional “stuffed”/accumulating lipids, they’re growing in dimension and might synthesize and launch hormones which in flip trigger inflammation thus growing the individuals danger for chronic diseases. Such inflammatory responses could then result in, e.g., cardio-vascular diseases leading to coronary heart assaults and strokes, in addition to most cancers and diabetes. “It appears
    that evidently sildenafil prevented the fats cells in these mice from getting onto that slippery
    slope,” reviews Prof. Pfeifer. Total, the event of white cells appears to be healthier.

    More than half a billion overweight folks worldwide

    Globally, over half a billion individuals are overweight. Current examine has resulted in attention-grabbing beginning factors for additional analysis on this mechanism. “Sildenafil
    shouldn’t be solely in a position to reduce erectile issues, but it surely can even cut back
    the dangers of gaining extreme weight,” says Prof. Pfeifer. The researchers could have discovered a mechanism that enables changing the undesirable white fats cells into the “good” beige (brown-like) fats cells that “melt” away excess pounds. As well as, it is likely to be attainable to lower complications associated with obesity. “However this may should be confirmed
    in further research,” provides Dr. Kilic.

    Caution in opposition to premature utility

    Despite promising information, researchers warning the general public in opposition to the fallacy of pondering that popping some sildenafil will work to rapidly lose the additional pounds accumulated over the vacations. “We’re presently in the essential analysis stage,
    and all of the research have been solely carried out on mice,” stresses Prof. Pfeifer. It will likely be a good distance till doubtlessly appropriate medication for reducing white fats cells in people can be discovered.

  2. “Men with diabetes should be screened for erectile dysfunction and vice versa,” corresponding author Damiano Pizzol, MD, of Doctors of Africa Cuamm, in Mozambique, told Renal & Urology News. “They tend to develop erectile dysfunction 10 to 15 years earlier than those without diabetes.” He added that screening for ED should be part of routine assessment of cardiovascular risk in men with diabetes, given underlying vasculopathy and increasing evidence of a direct link with cardiovascular disease.

  3. These activities damage the blood vessels resulting in reduced blood flow to the penis. Doctors say that ED might also be caused due to side effects of certain blood pressure drugs and antidepressants.

  4. Ailments involved with the heart or blood vessels are called cardiovascular disorders. Stroke, heart failure, coronary heart arrhythmia are cardiovascular disorders and they may outcome in erectile dysfunction. Cardiovascular disorders are induced by numerous variables which include significant blood cholesterol, diabetic issues and other these types of ailments. The greatest way to stay clear of this sort of health conditions is healthier life style decisions and work out.

  5. Sildenafil significantly improved erection quality across all age groups of men with ED. Efficacy improvements with sildenafil were consistent with the QEQ, IIEF, and EDITS. AEs were comparable across age groups. ClinicalTrials.gov ID: NCT00159900, NCT00147628, NCT00301262, NCT00343200.

  6. The report offers competitive pipeline landscape of Erectile Dysfunction. The report gives the promoted medication information and facts such as its sales, enhancement activities and facts of patent expiry. The report gives the perception of current and potential marketplace for Erectile Dysfunction. The report gives pipeline products and solutions under drug profile segment which involves item description, MOA, licensors & collaborators, enhancement companion and chemical information. Protection of the Erectile Dysfunction pipeline on the foundation of target, MOA, route of administration, know-how included and molecule sort. The report testimonials vital gamers concerned in the therapeutics enhancement for Erectile Dysfunction and also give firm profiling. The report also offers the details of dormant pipeline assignments. Pipeline merchandise coverage primarily based on different stages of enhancement ranging from preregistration till discovery and undisclosed levels and Presents pipeline evaluation by monotherapy and combination remedy products and solutions, stage of advancement and molecule form.

  7. Their meta-analysis, published online in Diabetic Medicine, showed that ED occurred in 52.5 of men with diabetes, after adjusting for publication bias. The rate was significantly higher among those with type 2 compared with type 1 diabetes (66.3 vs 37.5). The highest prevalence rate (82.2) was found among the 17 studies that identified ED using the Sexual Health Inventory for Men. Overall, having diabetes was associated with 3.62 times greater risk of ED.

  8. Hypertension is the medical ailment in which the blood tension in arteries is persistently elevated. These types of significant blood tension can guide to erectile dysfunction. It is normally prompted by unhealthy life-style and bad food items routines. Having wholesome food and working out consistently can assist keep hypertension at bay and as a result, steer clear of erectile dysfunction

  9. The purpose of this review was to evaluate erection excellent with sildenafil vs placebo and adverse occasions (AEs) in accordance to age (≤45, 46-55 and ≥56 yrs) in 997 gentlemen with erectile dysfunction (ED) using pooled data from 4 randomized, double-blind, placebo-managed, versatile-dose trials.

  10. Advancements in QEQ scores with sildenafil vs placebo were being major (P<.0001) for the overall sample (33.7 sildenafil 8.1 placebo) and each age group (≤45 years: 38.5 sildenafil, 13.9 placebo 46-55 years: 34.9 sildenafil, 5.8 placebo ≥56 years: 26.9 sildenafil, 4.9 placebo). IIEF Erectile Function domain (P<.0001), question 3 (achieving erection P<.003), and question 4 (maintaining erection P<.001) scores also improved significantly for the overall sample and each age group. Treatment satisfaction was significantly greater (P<.0001) with sildenafil vs placebo for the overall sample and each age group. The most common AEs with sildenafil were headache, flushing and nasal congestion in all age groups.

  11. Disorders linked with the heart or blood vessels are termed cardiovascular ailments. Stroke, coronary heart failure, coronary heart arrhythmia are cardiovascular illnesses and they may final result in erectile dysfunction. Cardiovascular diseases are triggered by many things which includes higher blood cholesterol, diabetic issues and other these kinds of disorders. The ideal way to steer clear of this sort of disorders is nutritious way of living possibilities and training.

  12. Advancements in QEQ scores with sildenafil vs placebo ended up major (P<.0001) for the overall sample (33.7 sildenafil 8.1 placebo) and each age group (≤45 years: 38.5 sildenafil, 13.9 placebo 46-55 years: 34.9 sildenafil, 5.8 placebo ≥56 years: 26.9 sildenafil, 4.9 placebo). IIEF Erectile Function domain (P<.0001), question 3 (achieving erection P<.003), and question 4 (maintaining erection P<.001) scores also improved significantly for the overall sample and each age group. Treatment satisfaction was significantly greater (P<.0001) with sildenafil vs placebo for the overall sample and each age group. The most common AEs with sildenafil were headache, flushing and nasal congestion in all age groups.

  13. Although hypertension and age older than 60 years were the only factors associated with diabetes-related ED in this study, longer diabetes duration, poor glycemic control, hyperlipidemia, sedentary lifestyle, smoking, and the presence of other diabetic complications have been noted in previous research. Patients should receive appropriate interventions related with these particular conditions, according to Dr Pizzol.

  14. It’s a phrase that concerns a selection of adult males. Erectile Dysfunction is additional popular than you might consider. For the uninitiated, erectile dysfunction is almost nothing but the incapacity to achieve or retain up a business erection all through sexual intercourse. When occasional erectile dysfunction is really rather typical thanks to worry and psychological elements, if you are struggling from frequent ED, it is a make any difference of worry and needs medical consideration. Normally, if you have problems finding an erection or come to feel a decreased interest in intercourse, it may be a indicator of erectile dysfunction. There are a selection of points you require to know about Erectile Dysfunction. But the most essential detail to be knowledgeable of is what results in it. Today, we give you 5 popular triggers of erectile dysfunction that males should be aware of.

  15. According to the National Institutes of Health, only 4 percent of men in their 50s and 17 percent of men in their 60s experience total inability to have an erection. The percentage of complete ED increases from 5 percent to 15 percent as age increases from 40 to 70 years.

  16. The report delivers competitive pipeline landscape of Erectile Dysfunction. The report offers the promoted medication info including its gross sales, development routines and details of patent expiry. The report offers the insight of present-day and upcoming industry for Erectile Dysfunction. The report offers pipeline products and solutions under drug profile area which involves merchandise description, MOA, licensors & collaborators, advancement associate and chemical details. Protection of the Erectile Dysfunction pipeline on the basis of focus on, MOA, route of administration, know-how involved and molecule form. The report assessments essential gamers involved in the therapeutics development for Erectile Dysfunction and also present corporation profiling. The report also gives the data of dormant pipeline jobs. Pipeline merchandise coverage based on different phases of progress ranging from preregistration until discovery and undisclosed stages and Provides pipeline evaluation by monotherapy and mix therapy products and solutions, phase of enhancement and molecule sort.

  17. These activities damage the blood vessels resulting in reduced blood flow to the penis. Doctors say that ED might also be caused due to side effects of certain blood pressure drugs and antidepressants.

  18. The aim of this examine was to assess erection high quality with sildenafil vs placebo and adverse occasions (AEs) according to age (≤45, forty six-fifty five and ≥56 years) in 997 guys with erectile dysfunction (ED) utilizing pooled info from 4 randomized, double-blind, placebo-controlled, flexible-dose trials.

  19. According to the National Institutes of Health, only 4 percent of men in their 50s and 17 percent of men in their 60s experience total inability to have an erection. The percentage of complete ED increases from 5 percent to 15 percent as age increases from 40 to 70 years.

  20. Their meta-analysis, published online in Diabetic Medicine, showed that ED occurred in 52.5 of men with diabetes, after adjusting for publication bias. The rate was significantly higher among those with type 2 compared with type 1 diabetes (66.3 vs 37.5). The highest prevalence rate (82.2) was found among the 17 studies that identified ED using the Sexual Health Inventory for Men. Overall, having diabetes was associated with 3.62 times greater risk of ED.

  21. In a country where any mention of penis, phallus, that-thing-between-the-legs takes place only in the context of sexual innuendos and boastful size comparisons, it’s difficult for men to have an open conversation about Erectile Dysfunction.

  22. These activities damage the blood vessels resulting in reduced blood flow to the penis. Doctors say that ED might also be caused due to side effects of certain blood pressure drugs and antidepressants.

  23. Sildenafil significantly improved erection quality across all age groups of men with ED. Efficacy improvements with sildenafil were consistent with the QEQ, IIEF, and EDITS. AEs were comparable across age groups. ClinicalTrials.gov ID: NCT00159900, NCT00147628, NCT00301262, NCT00343200.

  24. Hypertension is the professional medical ailment in which the blood pressure in arteries is persistently elevated. Such substantial blood strain can lead to erectile dysfunction. It is generally brought on by harmful life style and poor food patterns. Taking in healthy food and training on a regular basis can help maintain hypertension at bay and hence, stay away from erectile dysfunction

  25. Erectile Dysfunction (ED) or impotence is the inability to get and/or sustain an erection long enough to have sexual intercourse. Having erection issues at times doesn’t necessarily mean that you have ED. But, having consistent and repeated erection issues might require a visit to the doctor. Without proper treatment, ED can make sexual intercourse quite difficult.

  26. “Men with diabetes should be screened for erectile dysfunction and vice versa,” corresponding author Damiano Pizzol, MD, of Doctors of Africa Cuamm, in Mozambique, told Renal & Urology News. “They tend to develop erectile dysfunction 10 to 15 years earlier than those without diabetes.” He added that screening for ED should be part of routine assessment of cardiovascular risk in men with diabetes, given underlying vasculopathy and increasing evidence of a direct link with cardiovascular disease.

  27. Although hypertension and age older than 60 years were the only factors associated with diabetes-related ED in this study, longer diabetes duration, poor glycemic control, hyperlipidemia, sedentary lifestyle, smoking, and the presence of other diabetic complications have been noted in previous research. Patients should receive appropriate interventions related with these particular conditions, according to Dr Pizzol.

  28. The trials integrated six- to 10-week procedure intervals. The commencing sildenafil dose was 50 mg, taken ~1 hour ahead of sexual action but not additional than when day by day, with subsequent adjustment to 100 or twenty five mg dependent on efficacy and safety. Exclusion standards provided blood strain a hundred and seventy/a hundred and ten mmHg, using nitrate treatment or nitric oxide donors, significant cardiac failure/unstable angina or the latest stroke or myocardial infarction. Adjustments from baseline in Good quality of Erection Questionnaire (QEQ), Intercontinental Index of Erectile Operate (IIEF) and Erectile Dysfunction Stock of Treatment method Satisfaction (EDITS) scores ended up analysed.

  29. Erectile Dysfunction- Aggressive Landscape, Pipeline and Market Examination, 2017, report gives thorough insights about promoted and pipeline medicines across this Mechanism of motion. Essential objective of the report is to establish the knowing for all the marketed and pipeline medications that slide under Erectile Dysfunction. This report provides facts on the therapeutic progress based on Erectile Dysfunction system of action dealing with about a hundred and twenty+ energetic pipeline drugs. Report covers the solution medical trials data and other progress actions which include technological innovation, licensing, collaborations, acquisitions, fundings, patent and USFDA & EMA designations specifics. Report consists of the development and sale functions for promoted medicines. Delve Insight’s Report also assesses the Erectile Dysfunction therapeutics by Monotherapy, Blend merchandise, Molecule style and Route of Administration. The report also handles the info for 28+ lively companies involved in the therapeutic improvement of the solutions

  30. According to the National Institutes of Health, only 4 percent of men in their 50s and 17 percent of men in their 60s experience total inability to have an erection. The percentage of complete ED increases from 5 percent to 15 percent as age increases from 40 to 70 years.

  31. Their meta-analysis, published online in Diabetic Medicine, showed that ED occurred in 52.5 of men with diabetes, after adjusting for publication bias. The rate was significantly higher among those with type 2 compared with type 1 diabetes (66.3 vs 37.5). The highest prevalence rate (82.2) was found among the 17 studies that identified ED using the Sexual Health Inventory for Men. Overall, having diabetes was associated with 3.62 times greater risk of ED.

  32. The report offers competitive pipeline landscape of Erectile Dysfunction. The report presents the marketed medicines info including its sales, advancement actions and specifics of patent expiry. The report supplies the insight of present and potential current market for Erectile Dysfunction. The report offers pipeline merchandise underneath drug profile segment which consists of product description, MOA, licensors & collaborators, improvement companion and chemical information and facts. Protection of the Erectile Dysfunction pipeline on the foundation of goal, MOA, route of administration, technological know-how associated and molecule sort. The report critiques essential players associated in the therapeutics advancement for Erectile Dysfunction and also deliver business profiling. The report also presents the facts of dormant pipeline initiatives. Pipeline merchandise protection based on a variety of phases of enhancement ranging from preregistration until discovery and undisclosed phases and Supplies pipeline assessment by monotherapy and blend therapy products and solutions, stage of development and molecule type.

  33. And then there is old age. It has been observed that erectile dysfunction is prevalent amid adult men older than fifty several years of age. Nonetheless, irrespective of age, erectile dysfunction can be taken care of.Most of these triggers can be avoided by taking very good care of your health and fitness. Nonetheless, if you do stop up going through the signs or symptoms of erectile dysfunction, you should really seek advice from a medical professional and get on your own treated to get pleasure from a content and fulfilling sexual life.

  34. Stress is a major cause of ED, especially in young adults. In many cases, they aren’t able to perform due to unrealistic expectations. Even lifestyle issues like smoking, excessive drinking and drug abuse can cause ED.

  35. Shubh Mangal Savdhan releases this week. The promos have everyone guffawing, passing snide remarks and sniggering. In the film, the protagonist (Ayushmann Khurrana) suffers from Erectile Dysfunction (ED) which threatens to sabotage his wedding. Despite all the laughs it has given us, it has also opened up a much-needed conversation about men’s sexual health issues.

  36. “Men with diabetes should be screened for erectile dysfunction and vice versa,” corresponding author Damiano Pizzol, MD, of Doctors of Africa Cuamm, in Mozambique, told Renal & Urology News. “They tend to develop erectile dysfunction 10 to 15 years earlier than those without diabetes.” He added that screening for ED should be part of routine assessment of cardiovascular risk in men with diabetes, given underlying vasculopathy and increasing evidence of a direct link with cardiovascular disease.

  37. Advancements in QEQ scores with sildenafil vs placebo were important (P<.0001) for the overall sample (33.7 sildenafil 8.1 placebo) and each age group (≤45 years: 38.5 sildenafil, 13.9 placebo 46-55 years: 34.9 sildenafil, 5.8 placebo ≥56 years: 26.9 sildenafil, 4.9 placebo). IIEF Erectile Function domain (P<.0001), question 3 (achieving erection P<.003), and question 4 (maintaining erection P<.001) scores also improved significantly for the overall sample and each age group. Treatment satisfaction was significantly greater (P<.0001) with sildenafil vs placebo for the overall sample and each age group. The most common AEs with sildenafil were headache, flushing and nasal congestion in all age groups.

  38. The report gives aggressive pipeline landscape of Erectile Dysfunction. The report delivers the marketed drugs details together with its income, development things to do and information of patent expiry. The report supplies the insight of present-day and foreseeable future industry for Erectile Dysfunction. The report gives pipeline products underneath drug profile section which involves item description, MOA, licensors & collaborators, enhancement associate and chemical information and facts. Protection of the Erectile Dysfunction pipeline on the foundation of focus on, MOA, route of administration, engineering concerned and molecule form. The report evaluations essential players involved in the therapeutics advancement for Erectile Dysfunction and also provide organization profiling. The report also provides the data of dormant pipeline jobs. Pipeline products and solutions protection based on many stages of advancement ranging from preregistration until discovery and undisclosed levels and Presents pipeline evaluation by monotherapy and mixture therapy products and solutions, stage of development and molecule variety.

  39. Erectile Dysfunction- Aggressive Landscape, Pipeline and Current market Assessment, 2017, report gives detailed insights about marketed and pipeline medicines throughout this System of action. Vital goal of the report is to build the comprehending for all the marketed and pipeline medicines that tumble less than Erectile Dysfunction. This report offers information on the therapeutic growth dependent on Erectile Dysfunction system of motion working with all-around a hundred and twenty+ active pipeline medicines. Report handles the item scientific trials info and other improvement activities such as technologies, licensing, collaborations, acquisitions, fundings, patent and USFDA & EMA designations particulars. Report has the progress and sale routines for promoted medicines. Delve Insight’s Report also assesses the Erectile Dysfunction therapeutics by Monotherapy, Blend merchandise, Molecule style and Route of Administration. The report also handles the information and facts for 28+ energetic businesses associated in the therapeutic progress of the items

  40. Ailments linked with the heart or blood vessels are termed cardiovascular conditions. Stroke, heart failure, coronary heart arrhythmia are cardiovascular conditions and they could consequence in erectile dysfunction. Cardiovascular disorders are brought on by numerous components such as high blood cholesterol, diabetic issues and other such circumstances. The most effective way to stay clear of this sort of health conditions is healthful lifestyle choices and workout.

  41. Illnesses associated with the heart or blood vessels are referred to as cardiovascular ailments. Stroke, coronary heart failure, coronary heart arrhythmia are cardiovascular illnesses and they may perhaps final result in erectile dysfunction. Cardiovascular disorders are brought on by a number of variables such as significant blood cholesterol, diabetic issues and other these kinds of disorders. The finest way to avoid these types of ailments is healthier way of life decisions and physical exercise.

  42. Sildenafil significantly improved erection quality across all age groups of men with ED. Efficacy improvements with sildenafil were consistent with the QEQ, IIEF, and EDITS. AEs were comparable across age groups. ClinicalTrials.gov ID: NCT00159900, NCT00147628, NCT00301262, NCT00343200.

  43. Data suggests that ED is reported by 1 in every 5 men. Until recently, ED was thought to affect only older men but recent studies show that even younger men might have ED.

  44. Erectile Dysfunction- Competitive Landscape, Pipeline and Market Examination, 2017, report presents comprehensive insights about promoted and pipeline medications throughout this System of motion. Vital aim of the report is to build the comprehension for all the marketed and pipeline medication that drop below Erectile Dysfunction. This report provides details on the therapeutic enhancement based mostly on Erectile Dysfunction mechanism of motion working with all around one hundred twenty+ active pipeline medication. Report addresses the products medical trials facts and other improvement actions together with technologies, licensing, collaborations, acquisitions, fundings, patent and USFDA & EMA designations particulars. Report contains the enhancement and sale pursuits for marketed medications. Delve Insight’s Report also assesses the Erectile Dysfunction therapeutics by Monotherapy, Mixture solutions, Molecule type and Route of Administration. The report also addresses the data for 28+ lively firms involved in the therapeutic development of the merchandise

  45. Stress is a major cause of ED, especially in young adults. In many cases, they aren’t able to perform due to unrealistic expectations. Even lifestyle issues like smoking, excessive drinking and drug abuse can cause ED.

  46. “Men with diabetes should be screened for erectile dysfunction and vice versa,” corresponding author Damiano Pizzol, MD, of Doctors of Africa Cuamm, in Mozambique, told Renal & Urology News. “They tend to develop erectile dysfunction 10 to 15 years earlier than those without diabetes.” He added that screening for ED should be part of routine assessment of cardiovascular risk in men with diabetes, given underlying vasculopathy and increasing evidence of a direct link with cardiovascular disease.

  47. Prescription drugs have an affect on your nervous program and some even block your testosterone creating erectile dysfunctions. Smoking impacts your blood vessels and outcomes in blockage of arterial blood supply to the penis consequently foremost to erectile dysfunction. Saying no to prescription drugs and cigarette smoking is indirectly stating sure to intercourse.

  48. It is a term that concerns a variety of men. Erectile Dysfunction is far more widespread than you may believe. For the uninitiated, erectile dysfunction is very little but the lack of ability to attain or hold up a business erection in the course of sexual intercourse. Whilst occasional erectile dysfunction is actually rather widespread because of to strain and psychological factors, if you are suffering from recurrent ED, it is a issue of worry and needs healthcare consideration. Commonly, if you have trouble finding an erection or come to feel a minimized desire in sexual intercourse, it may possibly be a sign of erectile dysfunction. There are a selection of points you will need to know about Erectile Dysfunction. But the most crucial issue to be knowledgeable of is what causes it. Today, we give you 5 prevalent triggers of erectile dysfunction that men ought to be mindful of.

  49. Sildenafil significantly improved erection quality across all age groups of men with ED. Efficacy improvements with sildenafil were consistent with the QEQ, IIEF, and EDITS. AEs were comparable across age groups. ClinicalTrials.gov ID: NCT00159900, NCT00147628, NCT00301262, NCT00343200.

  50. “Considering the association between depressive symptoms and erectile dysfunction, especially in diabetic patients, management should be multidisciplinary,” Dr Pizzol added. “In addition to the skills and expertise of the metabolic diseases specialist and traditional pharmacological therapy, psychosexual counseling and specialist andrologist/urologist advice is necessary.”

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  374. West Bromwich Albion make a trip up the North
    East as they clash with Newcastle United in Saturday night’s
    Premier League encounter.

    Rafa Benitez’s side were on a four-game winning streak which was enough for them to secure their safety.

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    Salomon Rondon has been outstanding in front of goal
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